2 Mar, 1940
HMS Berwick (Capt I.M. Palmer, DSC, RN) intercepts the German merchant Wolfsburg (6201 GRT) north of Iceland in position 67º50'N, 22º45'W. However before the German ship can be captured she is scuttled by her own crew. (see map)

6 Mar, 1940
HMS Berwick (Capt I.M. Palmer, DSC, RN) intercepts the German merchant Uruguay (5846 GRT) north-east of Iceland in position 68º00'N, 15º00'W. However before the German ship can be captured she is scuttled by her own crew. (see map)

9 Apr, 1940
HMS Berwick (Capt I.M. Palmer, DSC, RN) participated in the Norwegian campaign. On completion of naval operations off Norway, was allocated to Force "H" at Gibraltar.

7 Nov, 1940
HMS Berwick (Capt. G.L. Warren, RN) refueled at Gibraltar then left for Alexandria in company of battleship HMS Barham (Capt G.C. Cooke, RN), light cruiser HMS Glasgow (Capt. H. Hickling, RN) and the destroyers HMS Encounter (Lt.Cdr. E.V.St J. Morgan, RN), HMS Gallant (Lt.Cdr. C.P.F. Brown, RN), HMS Greyhound (Cdr. W.R. Marshall A'Deane, DSC, RN) and HMS Griffin (Lt.Cdr J. Lee-Barber, DSO, RN).

11 Nov, 1940
HMS Berwick (Capt. G.L. Warren, RN) escorted the carrier HMS Illustrious (Capt. D.W. Boyd, DSC, RN) in her succesful raid against the Italian battle fleet in Taranto harbor. Later in the month escorted convoys between Egypt and Greece.

27 Nov, 1940
HMS Berwick (Capt. G.L. Warren, RN) had received orders to go to Freetown on 24 November, escorting carrier HMS Formidable (Capt. A.W.La T. Bisset, RN) with sistership HMS Norfolk (Capt. A.J.L. Phillips, RN), but the orders were amended to allocate her to convoy escorts in the North Atlantic.
While on passage to Gibraltar, an Italian Squadron comprising the battleships Vittorio Veneto and Andrea Doria attempted engaging the British, resulting in the Battle of Capo Teulada.
In the course of the balistic contact, at 1222 hrs Berwick sustained a 203-mm (8") hit on "X" turret, with 7 dead and 9 wounded, and another at 1235 hrs, probably another 203 mm, which exploded in the Officer's quarters.

25 Dec, 1940
Escorting convoy WS.5a, a troop convoy to the Middle East, came under attack from the German heavy cruiser Admiral Hipper about 700 nautical miles west of Cape Finisterre, Spain in position 43º39'N, 25º08'W. Berwick engaged the attacker but got the worse of the encounter, HMS Berwick (Capt. G.L. Warren, RN) had received four hits one being a direct hit on the forward turret which killed five Royal Marines, repairs lasting until June 1941. Two of the merchants in the convoy were lightly damaged. The Admiral Hipper retired from the fray and she eventually reached the safety of Brest.

From 1941 to 1945 she was attached to the Home Fleet, mainly escorting convoys to North Russia and operating in the northern North Sea. In February 1942 escorted the carriers which attacked the Tirpitz in her anchorage at Altenfjord and again in 1944-45 but on the whole the remainder of her career was uneventful. (see map)