1939-40: Convoy escorts with the Halifax Escort Force. carried £10 million in gold to Canada.

1 Jan, 1940
Allocated to the Home Fleet for the Norwegian Campaign. In April-May supported Army operations in the Narvik area.

19 Apr, 1940
HMS Enterprise (Capt. J.C. Annesley, DSO, RN) was fired upon by U 65 but the torpedoes missed.

1 Jun, 1940
In June 1940 she was reassigned to Force "H", operating out of Gibraltar.

9 Jul, 1940

This photograph show HMS Valiant (nearest to the camera) and HMS Resolution and is most likely taken during an Italian air attack (by SM 79 bombers) against Force H on 9 July 1940. The photograph is taken from HMS Enterprise.

Photograph with thanks to John Hancocks whose father Lt.(E) J.P. Hancocks served at HMS Enterprise during that time.

1 Dec, 1940
By the end of 1940 was operating in the South Atlantic, unsuccesfully hunting for Thor, then transferred to the Indian Ocean when Admiral Scheer appeared there but, again, she had no success.
In 1942 she was in the East Indies & Australian waters, operating with sistership Emerald in the Eastern Fleet.
From the end of 1942 to 10/43 was under refit in the UK, being then allocated to the Home Fleet, mainly for the purpose of hunting down blockade runners in Biscay.

28 Dec, 1943
HMS Enterprise (Capt. H.T.W. Grant, RCN) attempting the interception of the arriving German blockade runner Alsterufer in the Bay of Biscay with HMS Glasgow (Capt. C.P. Clarke, RN), ran into the freighter's covering group, consisting of the German destroyer Z 27 and the German torpedo boats T 22, T 25 and T 26.

In a spirited gun action, the heavier British artillery had the better of the Germans and only T 22 was able to return to port.

5 Jan, 1945
Placed in reserve but later reactivated for trooping duties. Returned to the UK on 13 January 1946, handed over for scrapping on 11 April and arrived at Newport on 21 April.