May of 1943 was the turning point in the Battle of the Atlantic, during which the Third Reich lost 41 U-boats which constituted 25% of its operational strength at the time.
Germany never recovered from this disaster and Dönitz withdrew all but token number of U-boats from battle. This month has been called "Stalingrad of the U-boat arm" by some.
| Date | U-boat | Crew | Dead | Survivors | Notes | |
| 2 May | U-465 | + | 48 | 48 | 0 | |
| 4 May | U-109 | + | 52 | 52 | 0 | |
| 4 May | U-439 | 49 | 40 | 9 | ||
| 4 May | U-659 | 47 | 44 | 3 | ||
| 5 May | U-638 | + | 44 | 44 | 0 | |
| 6 May | U-125 | + | 54 | 54 | 0 | |
| 6 May | U-192 | + | 55 | 55 | 0 | |
| 6 May | U-438 | + | 48 | 48 | 0 | |
| 6 May | U-531 | + | 54 | 54 | 0 | |
| 6 May | U-630 | + | 47 | 47 | 0 | |
| 7 May | U-209 | + | 46 | 46 | 0 | |
| 7 May | U-447 | + | 48 | 48 | 0 | |
| 8 May | U-663 | + | 49 | 49 | 0 | |
| 11 May | U-528 | 56 | 11 | 45 | ||
| 12 May | U-89 | + | 48 | 48 | 0 | |
| 12 May | U-186 | + | 53 | 53 | 0 | |
| 12 May | U-456 | + | 49 | 49 | 0 | |
| 13 May | U-753 | + | 47 | 47 | 0 | |
| 14 May | U-237 | - | 1 | - | ||
| 14 May | U-640 | + | 49 | 49 | 0 | |
| 15 May | U-176 | + | 53 | 53 | 0 | |
| 15 May | U-266 | + | 47 | 47 | 0 | |
| 16 May | U-182 | + | 61 | 61 | 0 | |
| 16 May | U-463 | + | 57 | 57 | 0 | |
| 17 May | U-128 | 54 | 7 | 47 | ||
| 17 May | U-646 | + | 46 | 46 | 0 | |
| 17 May | U-657 | + | 47 | 47 | 0 | |
| 19 May | U-273 | + | 46 | 46 | 0 | |
| 19 May | U-954 | + | 47 | 47 | 0 | |
| 20 May | U-258 | + | 49 | 49 | 0 | |
| 21 May | U-303 | 48 | 20 | 28 | ||
| 21 May | U-381 | + | 47 | 47 | 0 | |
| 22 May | U-569 | 46 | 21 | 25 | Scuttled | |
| 23 May | U-752 | 46 | 29 | 17 | ||
| 25 May | U-414 | + | 47 | 47 | 0 | |
| 25 May | U-467 | + | 46 | 46 | 0 | |
| 26 May | U-436 | + | 47 | 47 | 0 | |
| 28 May | U-304 | + | 46 | 46 | 0 | |
| 28 May | U-755 | 49 | 40 | 9 | ||
| 31 May | U-440 | + | 46 | 46 | 0 | |
| 31 May | U-563 | + | 49 | 49 | 0 |
41 U-boats lost during May 1943 (1785 men died and 183 men survived those losses)
+ means that the boat was lost with all hands.



